| Date | Location | Result | |
| May 18, 2000 | St. Petersburg, FL | South Florida 10, Louisville Cardinals 6 | Box score |
| May 17, 2000 | St. Petersburg, FL | Houston Cougars 4, Louisville Cardinals 3 | Box score |
| May 14, 2000 | Louisville, KY | Louisville Cardinals 7, UNC Charlotte 5 | Box score |
| May 13, 2000 | Louisville, KY | UNC Charlotte 9, Louisville Cardinals 1 | Box score |
| May 12, 2000 | Louisville, KY | Louisville Cardinals 7, UNC Charlotte 5 | Box score |
| May 07, 2000 | Houston, TX | Houston Cougars 5, Louisville Cardinals 2 | Box score |
| May 06, 2000 | Houston, TX | Houston Cougars 5, Louisville Cardinals 2 | Box score |
| May 05, 2000 | Houston, TX | Houston Cougars 14, Louisville Cardinals 2 | Box score |
| May 02, 2000 | Clarksville, TN | Austin Peay 11, Louisville Cardinals 8 | Box score |
| Apr 30, 2000 | Louisville, KY | UAB Blazers 7, Louisville Cardinals 6 | Box score |
| Apr 29, 2000 | Louisville, KY | UAB Blazers 15, Louisville Cardinals 2 | Box score |
| Apr 28, 2000 | Louisville, KY | Louisville Cardinals 8, UAB Blazers 3 | Box score |
| Apr 25, 2000 | Louisville, KY | Kentucky Wildcats 13, Louisville Cardinals 7 | Box score |
| Apr 22, 2000 | St. Louis, MO | Saint Louis 10, Louisville Cardinals 6 | Box score |
| Apr 22, 2000 | St. Louis, MO | Louisville Cardinals 10, Saint Louis 6 | Box score |
| Apr 21, 2000 | St. Louis, MO | Louisville Cardinals 9, Saint Louis 7 | Box score |
| Apr 19, 2000 | Louisville, KY | Louisville Cardinals 8, Xavier 4 | Box score |
| Apr 18, 2000 | Louisville, KY | Morehead State 14, Louisville Cardinals 9 | Box score |
| Apr 16, 2000 | Louisville, KY | Memphis Tigers 21, Louisville Cardinals 14 | Box score |
| Apr 15, 2000 | Louisville, KY | Memphis Tigers 7, Louisville Cardinals 4 | Box score |
| Apr 14, 2000 | Louisville, KY | Louisville Cardinals 7, Memphis Tigers 1 | Box score |
| Apr 12, 2000 | Lexington, KY | Kentucky Wildcats 10, Louisville Cardinals 3 | Box score |
| Apr 09, 2000 | Hattiesburg, MS | Southern Miss 15, Louisville Cardinals 3 | Box score |
| Apr 08, 2000 | Hattiesburg, MS | Southern Miss 8, Louisville Cardinals 4 | Box score |
| Apr 07, 2000 | Hattiesburg, MS | Southern Miss 5, Louisville Cardinals 2 | Box score |
| Apr 05, 2000 | Evansville, IN | Evansville Aces 11, Louisville Cardinals 4 | Box score |
| Apr 02, 2000 | Tampa, FL | South Florida 8, Louisville Cardinals 4 | Box score |
| Apr 01, 2000 | Tampa, FL | Louisville Cardinals 10, South Florida 8 | Box score |
| Mar 31, 2000 | Tampa, FL | Louisville Cardinals 16, South Florida 10 | Box score |
| Mar 26, 2000 | Louisville, KY | Cincinnati Bearcats 9, Louisville Cardinals 7 | Box score |
| Mar 25, 2000 | Louisville, KY | Louisville Cardinals 7, Cincinnati Bearcats 6 | Box score |
| Mar 24, 2000 | Louisville, KY | Cincinnati Bearcats 6, Louisville Cardinals 3 | Box score |
| Mar 22, 2000 | Bowling Green, KY | Louisville Cardinals 8, Western Kentucky 7 | Box score |
| Mar 19, 2000 | New Orleans, LA | Louisville Cardinals 3, Tulane Green Wave 3 | Box score |
| Mar 19, 2000 | New Orleans, LA | Tulane Green Wave 15, Louisville Cardinals 0 | Box score |
| Mar 17, 2000 | New Orleans, LA | Louisville Cardinals 11, Tulane Green Wave 1 | Box score |
| Mar 14, 2000 | Louisville, KY | Austin Peay 5, Louisville Cardinals 4 | Box score |
| Mar 12, 2000 | Louisville, KY | Miami(OH) 13, Louisville Cardinals 0 | Box score |
| Mar 12, 2000 | Louisville, KY | Louisville Cardinals 4, Miami(OH) 3 | Box score |
| Mar 10, 2000 | Louisville, KY | Louisville Cardinals 4, Miami(OH) 3 | Box score |
| Mar 08, 2000 | Gainesville, FL | Florida Gators 13, Louisville Cardinals 12 | Box score |
| Mar 07, 2000 | Gainesville, FL | Louisville Cardinals 11, Florida Gators 7 | Box score |
| Mar 05, 2000 | Louisville, Ky | Wright State 5, Louisville Cardinals 3 | Box score |
| Mar 04, 2000 | Louisville, Ky. | Louisville Cardinals 7, Kent University 4 | Box score |
| Mar 04, 2000 | Louisville, Ky. | Northern Iowa 14, Louisville Cardinals 4 | Box score |
| Mar 03, 2000 | Louisville, Ky | Kent University 8, Louisville Cardinals 7 | Box score |
| Mar 01, 2000 | Louisville, KY | Evansville Aces 5, Louisville Cardinals 2 | Box score |
| Feb 27, 2000 | Nashville, TN | Vanderbilt 9, Louisville Cardinals 5 | Box score |
| Feb 26, 2000 | Nashville, TN | Vanderbilt 6, Louisville Cardinals 5 | Box score |
| Feb 25, 2000 | Nashville, TN | Vanderbilt 18, Louisville Cardinals 5 | Box score |
| Feb 23, 2000 | Louisville, KY | Louisville Cardinals 6, Western Kentucky 4 | Box score |
| Feb 20, 2000 | Miami, FL | Fla. International 8, Louisville Cardinals 1 | Box score |
| Feb 19, 2000 | Miami, FL | Fla. International 6, Louisville Cardinals 5 | Box score |
| Feb 18, 2000 | Miami, FL | Fla. International 7, Louisville Cardinals 6 | Box score |
| Feb 12, 2000 | Louisville, KY | Evansville Aces 6, Louisville Cardinals 1 | Box score |